We also identified and compared statistically significant regulators that may mediate the regulation of hypoxically induced genes in cells bearing the Hap1 expression plasmid (HAP1) and the empty vector (Δhap1) and those that mediate heme deficiency-induced (heme-suppressed) genes (Figure 5A and Figure S3). This evidence concerns the gene HAP1 and hyperinsulinemic hypoglycemia, familial, 4.