EBV-positive B-cells expressing LMP1 or cells transiently transfected to express LMP1 manifest an upregulation of CTNB1, a component of the Wnt signaling pathway whose increased stability has been associated with cancer (see section on Colorectal cancers are associated with defects in the regulation of CTNB1 (β-catenin) stability through mutations in adenomatous polyposis coli) [197]. The gene discussed is APC; the disease is colorectal cancer.