Similarly, once the full in vivo ramifications of the UBP20 (USP20)/HIF1A (HIF-1κ/VHL (pVHL) interplay are understood (see DUBs and disease: UBP33/USP33/VDU1, UBP20/USP20/VDU2 and von Hippel-Lindau disease), modulation of these protein-protein interactions should allow regulation of HIF1A levels in von Hippel-Lindaudisease. This evidence concerns the gene VHL and von Hippel-Lindau disease.