EPHA2 and Age-related cataract: The existence of any such mechanism remains to be determined; however, it is interesting that the two SNPs in the EPHA2 region most associated with age-related cataracts (rs7543472 and rs11260867) lie outside the coding region near the 3′-end of the gene, which has been shown to harbor highly conserved translational control sequences that are believed to facilitate an RNA-based post-transcriptional mechanism for localized regulation of gene expression within cells [48,49].