It was recently reported that gene deletion for several members of the error-free branch of the PRR pathway, including RAD5 and SRS2, results in an expansion of CAG and CTG trinucleotide repeats (TNRs); expansion of such repeats have been associated with Huntington's disease and myotonic dystrophy [45]–[47]. The gene discussed is SHPRH; the disease is myotonic dystrophy.