The existence of OMIDI pairs (see Terminology and Abbreviations in Materials and Methods) in EGFR, the high frequency of allelic versus compound heterozygote doublets, the high frequency of closely spaced doublets, and the clustering in multiplets are consistent with chronocoordinate mutations contributing to at least a subset of the EGFR and TP53 doublet and multiplet mutations found in human lung cancer. This evidence concerns the gene EGFR and lung carcinoma.