In contrast to our observation, a study of oesophageal SCCs found that overexpression of Cav-1 was associated with LNM and a worse prognosis after surgery (Kato et al, 2002), suggesting that the effect of Cav-1 on metastasis progression could be tissue-specific as illustrated in the contradictory cases between breast cancer (Sloan et al, 2004) and prostate cancer (Williams et al, 2005). The gene discussed is CAV1; the disease is breast cancer.