Quantitative analysis of Tu-1, LNM-1, and Tu-2 samples revealed that expression of Cav-1 was significantly downregulated in LNM-1 compared with primary tumours (median WI=82.5 for LNM-1 vs median WI=127 for Tu-1 and 140 for Tu-2, P<0.0001) (Figure 1B left). This evidence concerns the gene CAV1 and neoplasm.