In contrast, it has been suggested that Cav-1 acts as a putative tumour and metastasis suppressor of breast cancer (Sloan et al, 2004; Williams et al, 2004; Williams and Lisanti, 2005), indicating that the role of Cav-1 in metastasis is cell-type specific and remains to be defined. This evidence concerns the gene CAV1 and neoplasm.