In addition, differentially altered proteins identified from the cDNA microarray analysis, including E-cadherin, EGFR, S100A2, protease-activated receptor-1, and CCR7, were confirmed in human HNSCC tissue samples (Wang et al, 2004; Zhang et al, 2004a, 2007; Muller et al, 2008). The gene discussed is CDH1; the disease is head and neck squamous cell carcinoma.