On the basis of these findings, it is plausible to suggest that restoration of Cav-1 could reverse the aggressive behaviour of highly metastatic tumour cells by modulating the vital integrin β1/Src-mediated cell–cell and cell–matrix machineries, leading to suppression of tumour growth and metastasis potential in late stage of tumour development (Figure 7). This evidence concerns the gene CAV1 and neoplasm.