KDR and ovarian carcinoma: Several retrospective clinical studies in ovarian cancer have also demonstrated that intratumoral VEGF and VEGFR-2 expression and the carriage of VEGF gene polymorphisms associated with an increased VEGF excretion are independent poor prognostic factors (Shen et al, 2000; Goodheart et al, 2005; Hefler et al, 2007).