Immunoblotting revealed that NB7M treatment of SKOV-3 affected the expression of two prominent members of the Cip/Kip family of cyclin-dependent kinase (CDK) inhibitors, which are key regulators involved in cell growth in vivo, in vitro, in tumour and normal tissues (Stillman, 1996; Albrecht et al, 1998; Pines, 1999): P27 (kip1) CDK was upregulated and p21 downregulated upon NB7M treatment (Figure 5D). Here, CIB1 is linked to neoplasm.