In the present study, we therefore explored the possibility that the TNF-2 allele of the G-308A polymorphism of the TNF-α gene is associated with changes in left ventricular (LV) dimensions and pump function after six months of medical therapy in patients with idiopathic dilated cardiomyopathy (IDC). The gene discussed is TNF; the disease is idiopathic dilated cardiomyopathy.