IFNB1 and Autoimmunity: Because IL-27 has been implicated in the mechanism of IFN-β- mediated suppression of autoimmunity and Th17 cell responses [28] we investigated the mRNA expression of IL-27p28 in MOG91–108-stimulated spenocytes from pMOG-, pMOG-IFNbeta- or pCI-treated rats.