TCF4 and adenocarcinoma: p-c-Jun, TCF4 and β-Catenin in the adenomas, and p-c-Jun and β-Catenin in the HGINs and adenocarcinomas showed significantly higher scores than in their adjacent normal colorectal epithelia, respectively (p < 0.05 by Wilcoxon matched pairs signed ranks test) (Additional file 1-Supplemental Table S1).