To investigate the relationships of p-c-Jun, TCF4, and β-Catenin with MMP7, whose promoter contains both functional AP-1 and TCF binding sites [19], we analyzed the correlation of the nuclear expression of p-c-Jun, TCF4 and β-Catenin with cytoplasmic MMP7 expression in colorectal tumors including adenomas, HGINs and adenocarcinomas. The gene discussed is TCF4; the disease is adenocarcinoma.