We also looked for genes involved in cell adhesion and migration and found integrin alpha 3, integrin beta 2 and intercellular adhesion molecule 1 to be upregulated in adenocarcinomas, while 6 genes, including the desmosomal cadherins desmoglein 3 and desmocollin 3, were significantly downregulated compared to normal lung tissue. The gene discussed is DSC3; the disease is adenocarcinoma.