Combinations of alleles PTGS1 c.639A, PLA2G2A c.435+230C, PPARG c.1431C, IL8 c.-352A, and MTHFR c.1286C determine "genotypic profiles" at significantly higher risk of CRC (OR 1.97, 95% CI 1.31–2.97), in a small percentage of the French population. The gene discussed is PTGS1; the disease is colorectal carcinoma.