Thus, to our knowledge, the synonymous polymorphism c.639C>A (p.Gly213Gly) that we found as having a predisposing effect on CRC (OR 1.24) at the heterozygous (CA) or homozygous state (AA), had not been examined within this context to date and its precise impact on PTGS1 activity would require further functional studies. This evidence concerns the gene PTGS1 and colorectal carcinoma.