Considering the data that there are no positive correlation between anti-mouse GPI antibodies and arthritis score [[29] and unpublished observation], and arthritis-resistant mice like C57BL/6 produce as high titres of anti-mouse GPI antibodies as DBA/1 when immunised with rhGPI (1 and unpublished observation), anti-mouse GPI antibodies may play a subordinate role in the development of GPI-induced arthritis and peptide-induced arthritis in DBA/1 mice. Here, GPI is linked to Arthritis.