In another study, PD153035 was non-specifically labeled either at the 6- or 7-methoxy positions and its biodistribution using PET in rats bearing EGFR-rich SH-SY5Y human neuroblastoma xenografts, revealed a low maximum tumor activity-uptake value of ~0.3% injected tracer dose per mL of tumor tissue (%ID/mL) at less than 10 min post injection [89]. This evidence concerns the gene EGFR and neoplasm.