In contrast, in faecal DNA SFRP2 methylation was proven to be a highly promising screening marker for colorectal cancer [34], even potent to detect early lesions like adenoma, aberrant crypt foci [35] and colorectal polyps [36] due to the absence of SFRP2 methylation in normal colonic mucosa. Here, SFRP2 is linked to colorectal cancer.