HFE and hemochromatosis type 1: This was in accordance with previous work by Pratiwi et al. [24] that showed by an extended linkage disequilibrium analysis in the hemochromatosis gene region, two distinct peaks of association, namely a highly significant association at D6S2239, localized in close proximity to HFE (14 kilobases telomeric) and at D6S105 [24].