PRODH along with its pseudogene are located at 22q11 is implicated in schizophrenia through a hemideletion syndrome at this locale, 22q11 deletion syndrome (22q11DS, Velo-Cardio-Facial syndrome, VCFS: OMIM #192430), which may be the strongest known risk factor for schizophrenia besides having a monozygotic twin with the disorder [2]–[6]. Here, PRODH is linked to schizophrenia.