Considering our data as well as previously reported data such as those on the differential anatomical apolipoprotein D (apoD) abnormalities in schizophrenia and bipolar disorder [90], it is tempting to suggest that the diversity in the clinical spectrum of mental disorders may, at least in part, be attributed to the different anatomical pattern of specific impairments in the neuronal circuits implicated in the disorders. This evidence concerns the gene APOD and schizophrenia.