Emerging genetic and molecular information acquired over the last 2 decades hasbegun to unravel the pathogenesis of thyroid cancer and in the future may open thedoor to potential novel therapies for patients with previously untreatable disease.Research focusing on PPARγ in avariety of cancer cell lines has implied a tumor suppressor function for wild-typePPARγ, while PPARγ downregulation or inhibition may be onefactor in the development of at least some thyroid cancer types. The gene discussed is PPARG; the disease is cancer.