Levels of Bax protein and c-myc, bothapoptosis-related proteins, were increased in a dose-dependentfashion by treatment with PPARγ ligand[13, 15],although one study found increased levels of a different apoptotic protein,Bcl-2, rather than of Bax [12].Inhibition of cell invasion [13],attachment [12, 17],and anchorage-independent growth on soft agar [12],all features of malignancy, are also seen with PPARγligand treatment in thyroid cancer cell lines. This evidence concerns the gene PPARG and thyroid cancer.