PPARG and thyroid tumor: Data from humans has also implicated a functional downregulation of PPARγ expression in human thyroid tumors thatdid not carry PPARγ translocations, in studies usingsemiquantitative PCR, real-time RT-PCR, and microarray analyses[28, 29].Furthermore, tumors with reduced PPARγexpression showed an increased incidence of distant metastases, local invasion, andareas of poor differentiation [28].