In a Dutch case-control cohort consisting of 780 patients with premature coronary atherosclerosis and 1414 controls, we found a higher prevalence of the APH1B Phe217Leu risk allele (G-allele) in the patients, albeit not statistically different (χ2 = 2.09, df = 1, p = 0.15; OR = 1.35; CI = 0.90–2.01). The gene discussed is APH1B; the disease is coronary atherosclerosis.