TGFB1 and hereditary disorder of connective tissue: The defect in BMP/TGF-β signaling that we have described is more consistent with the phenotype; impaired TGF-β signaling fits well with short stature in mouse and human, as increased TGF-β activity has been regarded as the cause of tall stature in Marfan syndrome, another inherited disorder of connective tissue [67], [68].