The minor allele of rs9402571, which was found to associate with a higher insulin secretion in the screening (TUEF) as well as the replication (EUGENE2) populations, associated almost significantly (p = 0.065; adjusted for age, family history of diabetes, and BMI) with a lower prevalence of type 2 diabetes (odds ratio: 0.845; 95%CI: 0.706–1.011), comparing the 659 diabetic patients with the non-diabetic 3798 METSIM participants. Here, INS is linked to diabetes mellitus.