FOXP3 and colorectal carcinoma: We could not identify a statistically significant influence of age or gender on the overall infiltration of CRC with FOXP3-positive cells, yet a younger age was associated with a lower number of FOXP3-positive cells in the stroma and a higher ratio of epithelial-to-stromal infiltration with FOXP3-positive cells (P=0.07 and P=0.08, respectively).