Similarly, tumours that had developed metastases in distant organs (M1) also showed a lower stromal infiltration with FOXP3-positive cells (median: 75.7 cells per 0.25 mm2 in M1 vs 171.6 cells per 0.25 mm2 in M0, P=0.01) compared with tumours without distant metastasis (M0), whereas the intraepithelial infiltration was not different (median: 5.1 cells per 0.25 mm2 in M1 vs 4.5 cells per 0.25 mm2 in M0, P=0.72). This evidence concerns the gene FOXP3 and neoplasm.