In addition, the numbers of CD3-positive T cells (370.8 cells per 0.25 mm2 in MSI-H vs 320.1 cells per 0.25 mm2 in MSS, P=0.06) and CD8-positive cells (107.4 cells per 0.25 mm2 in MSI-H vs 47.2 cells per 0.25 mm2 in MSS P=0.009) infiltrating the tumour stroma were higher in MSI-H CRCs. The gene discussed is CD8A; the disease is neoplasm.