In addition, the ratio between intraepithelial and stromal FOXP3-positive cells was significantly higher in the MSI-H CRC group (0.05 in MSI-H vs 0.01 in MSS, P<0.001), indicating that in MSI-H CRC, a larger proportion of the FOXP3-positive cells was located in the epithelial compartment of the tumour. Here, FOXP3 is linked to neoplasm.