FOXP3 and neoplasm: Concerning the mechanism underlying the increased numbers of tumour-infiltrating FOXP3-positive cells observed in CRCs of the MSI-H group, it is interesting to note that dendritic cells can expand Treg populations (Nagorsen et al, 2007), thus potentially explaining an increased frequency of FOXP3-positive cells in MSI-H CRCs as a consequence of a pronounced immune response observed in these lesions.