In CRC with nodal metastasis (N1/2), the number of stromal FOXP3-positive cells was significantly lower than in CRC without nodal metastasis (N0) (median: 136.9 cells per 0.25 mm2 in N1/2 vs 173.6 cells per 0.25 mm2 in N0, P=0.02), whereas the number of intraepithelial FOXP3-positive cells was not different between both groups (median: 5.4 cells per 0.25 mm2 in N1/2 vs 4.4 cells per 0.25 mm2 in N0, P=0.92). This evidence concerns the gene FOXP3 and colorectal carcinoma.