Our previous studies suggest that LPS could influence the progression of colorectal cancer through its receptor TLR4 (Toll-like receptor 4) [28] and the downstream transcription factor NFκB (nuclear factor-κB) [29], leading to release of factors from colon carcinoma cells capable of up-regulating endothelial cell adhesion molecules [30]. The gene discussed is TLR4; the disease is colon carcinoma.