CD4 and AIDS: These findings conveyed two points: first, in the cohort examined, the ZNRD1-C allele was unlikely to have an impact on disease independent of its LD with HLA-A10; and second, the influence of the HLA-A10/ZNRD1-C-containing haplotype on disease course occurs independent of an impact on the viral load, and that the influence of this haplotype is restricted mainly to the rate and extent of CD4+ T cell loss (assessed by cumulative CD4+ T cell count; Figure 2E), and by extension, on AIDS progression rates (Figure 2D).