ICAM2 and neuroblastoma: These results indicate that observations using neuroblastoma cells transfected to increase expression of ICAM-2 are unlikely to be due to artificial over-expression of this protein, since downregulation of endogenous ICAM-2 in SJNB-1A cells produced the expected phenotype: an inverse relationship between level of ICAM-2 expression with actin fiber redistribution and development of disseminated tumors in vivo was seen in both cDNA and RNAi transfected cell lines.