To address the possibility that the observed results were a consequence of artificial overexpression of ICAM-2, we used RNAi techniques to decrease the expression of ICAM-2 protein in SJNB-1A cells, the neuroblastoma cell line expressing the highest endogenous level of ICAM-2 expression (Fig. 1A) and investigated the phenotype of RNAi transfectants. The gene discussed is ICAM2; the disease is neuroblastoma.