ICAM2 and neuroblastoma: However, the hypothesis that the novel function for ICAM-2 described here depends at least partly on the association of membrane-bound ICAM-2 with α-actinin and actin is consistent with published reports documenting the role of α-actinin as a determinant of metastatic potential [4], [5], [40], [41] and the observation that α-actinin associates with an unknown membrane protein to decrease the tumorigenic or metastatic potential of neuroblastoma cells [7].