The early KS lesion is most probably initiated by HHV-8 induced production of pro-inflammatory cytokines IL-1, IL-6, tumour necrosis factor (TNF)-α, interferon (IFN)-γ and growth factors basic fibroblast growth factor (bFGF) and vascular endothelial cell growth factor (VEGF) that causes activation of endothelial cells followed by angiogenesis (Diagram 1) [1,10-12]. Here, FGF2 is linked to Kaposi's sarcoma.