DSP and obesity due to melanocortin 4 receptor deficiency: DE nsSNPs were found to map in genes with a role in cancer susceptibility (BRAC1 (+113705), BARD1 (+113705)), asthma and obesity (ADRB2 (+109690)), Crohn's disease (DLG5 (*604090)), myokymia (KCNA1 (*176260)), diabetes (OAS1 (*164350)), chronic lymphatic leukaemia (P2RX7 (*602566)) emphysema and liver disease (P I(+107400)), severe keratoderma (DSP (+125647)), and familial hypercholesterolemia (ABCA1 (+600046)).