AHCTF1 and hyperinsulinemic hypoglycemia, familial, 4: Unlike zebrafish Elys deficiency, partial Mcm5 knockdown (75% reduction) reduced levels of all other Mcm proteins analyzed, including Mcm2 (50% reduction), which may explain why survival of these cells was reduced by treatment with hydroxyurea and camptothecin whereas flo mutants were only affected by hydroxyurea.