Metastatic breast tumor cell lines show increased cell surface gp78/AMFR expression, however AMF/PGI uptake was increased only in metastatic MDA-435 cells that express gp78/AMFR and reduced Cav1 levels and not in MDA-231 cells expressing both gp78/AMFR and high levels of Cav1 [41]. The gene discussed is AMFR; the disease is breast neoplasm.