We previously showed that gp78/AMFR expression was elevated in metastatic MDA-435 and MDA-231 cells relative to non-metastatic MCF-7 and dysplastic MCF10A mammary tumor cells and that AMF/PGI-FITC uptake was selectively increased in MDA-435 cells that express reduced levels of Cav1 [41]. Here, AMFR is linked to breast cancer.