AMFR and neoplasm: AMF/PGI represents an ideal carrier for drug delivery in that it is a native protein circulating at high levels in serum [32]–[37], is the ligand for a receptor, gp78/AMFR, significantly associated with malignancy in a broad range of human cancer types [7] and is internalized via a distinct, tumor-associated raft-dependent endocytic pathway [40], [41].