AMF/PGI is selectively secreted by transformed cell lines and has been extensively implicated in the autocrine stimulation of tumor cell motility and proliferation through activation of PKC, Rho, Rho-GDI and p27Kip1 inducing reorganization of focal contacts and loss of E-cadherin via upregulation of the E-cadherin transcription repressor SNAIL [19]–[25]. The gene discussed is CDH1; the disease is neoplasm.