In this study, we show that raft-dependent uptake of AMF/PGI is specific for gp78/AMFR-positive/Cav1-negative metastatic colon cancer cells, does not target normal immune cells and occurs in vivo in subcutaneous K1735-M1 and B16-F1 melanoma tumor models. Here, AMFR is linked to malignant colon neoplasm.