Amongst the genes included as overexpressed in our prostate tumoral set, there are several well-established PC markers, such as AMACR [20] and HPN [21,22], or previously associated with PC, like those for ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5), tumor-associated calcium signal transducer 1 (TACSTD1), single-minded homolog 2 (SIM2) or myosin VI (MYO6) [25,26]. The gene discussed is SIM2; the disease is pachyonychia congenita.