Eighteen genes, including CDC3 and LAMA3 which are involved in the same pathways, showed significant differences between HCC cases with either cirrhosis or chronic active hepatitis (figure 2), whereas 21 genes, including FGFR1 and LAMA 3, showed significant differences between HCC with cirrhosis and HCC without cirrhosis. This evidence concerns the gene FGFR1 and hepatocellular carcinoma.