YWHAH, or 14-3-3 eta, is a member of the dimeric 14-3-3 family of signal transduction proteins that specifically binds to phosphorylated serine on a variety of signalling molecules, such as Bcl-2, MDMX, and Bax, thereby promoting cell survival and acting antiapoptotic in several tumor cells [85-87]. This evidence concerns the gene MDM4 and neoplasm.