WT1 and telomere syndrome: STS with high WT1 mRNA expression levels have poorer outcome than those with low levels [89,90].Ecteinascidin that has been shown to be effective against STS also increases expression of PAWR [92].PAWR inhibits the PKC (atypical protein kinase)-NF-(kappa)B (nuclear factor-(kappa)B)-XIAP pathway [91].