While short-term (24 h) exposure of insulinoma cell lines to SUs induced an increase in GLUT2 and GK mRNA, long-term (48–72 h) exposure induced a marked reduction of these glucose mobilizers [53], coupled with a reversible reduction in insulin content with no changes in Kir6.2 or SUR1 transcripts (72–144 h) [39]. This evidence concerns the gene GK and pancreatic insulinoma.