However, ETS-2 has also been implicated in prostate cancer [42] and together with other factors including ETS-1, SRC-1 (v-src avian sarcoma [Schmidt-Ruppin A-2] viral oncogene homolog), AIB-1 (nuclear receptor coactivator 3) and NcoR (nuclear receptor co-repressor) [43,44], breast cancer. This evidence concerns the gene NCOA3 and Familial prostate cancer.