A recent genome-wide association study demonstrated that one intronic single nucleotide polymorphism (SNP, rs2165241) and two exonic SNPs (rs1048661 [R141L] and rs3825942 [G153D]), which are located in the first exon of the lysyl oxidase like1 (LOXL1) gene on chromosome 15q24.1, are highly associated with exfoliation syndrome in Icelandic and Swedish populations while none of these SNPs were associated with primary open-angle glaucoma in either of the two populations [2]. Here, LOXL1 is linked to open-angle glaucoma.