Four immediate arm children had new clinically diagnosed acid fast bacilli smear-negative pulmonary tuberculosis (TB) at a median time of 60 weeks (range 48 to 72), and a median CD4 of 28% (IQR 22 – 37) and 637 cells/mm3 (IQR 568 – 894). The gene discussed is CD4; the disease is pulmonary tuberculosis.