A statistically significant increase in concentrations of 15 biomarker proteins (IL-1α, IL-1β, IL-6, IL-8, IL-12p40, IL-13, GCS-F, MCP-1, MIP-1α, MIP-1b, IFNα, TNFα, EGF, VEGF, and TNFRII) was found in the sera of melanoma patients compared with age- and sex-matched healthy controls (P < 0.05–P < 0.001). The gene discussed is IFNA2; the disease is melanoma.