The EORTC 18991 trial was undertaken to test the hypothesis that prolonged exposure to IFN through the use of newer PEG-coupled forms of IFN, given subcutaneously weekly have anti-angiogenic effects in stage III melanoma patients, where the primary endpoint chosen by the EORTC was distant metastasis-free survival (DMFS), and the secondary endpoint was overall survival (OS) [32]. The gene discussed is IFNA1; the disease is melanoma.