This will include use of neoadjuvant approaches, or the more intelligent evaluation of sentinel nodes in relation to the determinants of therapeutic benefit for IFN; second is to increase our knowledge regarding the critical biological determinants in every adjuvant trial, such as the induction of autoantibodies, and the definition of immunogenetic factors that can predict the susceptibility to autoimmunity. Here, IFNA1 is linked to Autoimmunity.