TRAF4 and invasive carcinoma: Finally, under optical microscopy, in in situ breast primary tumors exhibiting well-differentiated features, although the epithelial cells are malignant we observed a TRAF4 TJ pattern at the remaining cell-cell contacts (Figure 6 E), similar to that shown in normal epithelium (Figure 5), whereas invasive carcinomas are totally devoid of such staining (Figures 6 F and G), but exhibit cytoplasmic and/or nuclear staining [9], [10].