Interestingly, p38alpha has also been found to have a negative role in regulating both migration and invasion of pancreatic and breast carcinoma cells [11]–[12], [32] and its activity is reduced in hepatocellular carcinomas in comparison to adjacent normal tissue [62], suggesting that its down-regulation is not limited to just transformation and early tumorigenesis but also in later metastatic/aggressive stages. The gene discussed is MAPK14; the disease is hepatocellular carcinoma.