The involvement of the cAMP/PKA pathway in mediating tumor progression [35] together with the demonstrated integration of p38 with cAMP/PKA signaling in different cell systems [43], [57], [63], [64] focused our attention on the possibility that E7 transformation-dependent down-regulation of p38 involves the cAMP/PKA system. The gene discussed is MAPK14; the disease is neoplasm.