SOX10 and Waardenburg-Shah syndrome: These roles in development are reflected in the association of SOX10 with several congenital conditions in humans, particularly in Waardenburg-Shah syndrome (OMIM#277580), involving defects in pigmentation and the enteric nervous system [3,23], and in PCWH (OMIM#609136), a complex syndrome involving dysmyelination in the central and peripheral nervous systems with Waardenburg-Shah syndrome [6,24-26].