CBFA2T3 and leukemia: As a consequence of the leukemia-associated chromosome translocations t(8;21) and t(16;21), almost the entire MTG8 and MTG16 protein moieties are fused to the RHD domain of AML1, leading to the chimeric AML1-MTG8 and AML1-MTG16 proteins, respectively [1-3].