As a consequence of the leukemia-associated chromosome translocations t(8;21) and t(16;21), almost the entire MTG8 and MTG16 protein moieties are fused to the RHD domain of AML1, leading to the chimeric AML1-MTG8 and AML1-MTG16 proteins, respectively [1-3]. The gene discussed is RUNX1T1; the disease is leukemia.