XDH and hepatocellular carcinoma: Down-regulation of oxidoreductases in Hepatocellular carcinoma, when compared to surrounding non-neoplastic liver tissues, is well-documented in the literature, with examples that include 10-Formyltetrahydrofolate dehydrogenase, cytochrome oxidase, succinate dehydrogenase, monoamine oxidase, cytochrome P450, catalase, urate oxidase, D-amino acid oxidase, L-alpha-hydroxy acid oxidase, xanthine oxidase and (Cu/Zn) superoxide dismutase.