Clinical and experimental studies have demonstrated the role of lipoproteins in the decline of renal function with emphasis on glomerulosclerosis [25–28], neutrophil and macrophage infiltration [29] and upregulation of the cytokine interleukin (IL)-6 [30,31] or endothelial nitric oxide synthase [32]. The gene discussed is IL6; the disease is glomerulosclerosis.