For example, the cancer/testis antigen NY-ESO-1 was identified by screening an oesophageal cancer cDNA library and is regarded as one of most antigenic tumour antigens; antibody responses to NY-ESO-1 have been observed in 40-50% of patients with NY-ESO-1 expressing tumours and the presence of antibody strongly correlating with a CD8+ T-cell response to the antigen [5]. The gene discussed is CD8A; the disease is neoplasm.