IGHE and Allergy: 2S albumins from a variety of plant foods including tree nuts, grain legumes, spices, oil seeds and cereals have been reported to bind IgE from allergic patients ́ sera (Table 1).In last decade, Brazil nut 2S albumins attracted special attention from researchers and consumers when the gene encoding the 2S protein was transferred into transgenic soybeans in order to increase their levels of sulphur-containing amino acids; patients with a history of Brazil nut allergy had positive reactions to extracts of these genetically modified crops on skin prick tests and IgE-binding assays [3].