The known AT1R proangiogenic effect mainly results from VEGF, angiopoietin-2, and VEGFR2 up-regulation via EGFR transactivation [106] in tumor cells, as well as VEFG up-regulation in fibroblasts, the major stromal cellular components involved in tumor-related angiogenesis by activating NFkB, AP-1, and PKC activation. This evidence concerns the gene ANGPT2 and neoplasm.