MKI67 and neoplasm: These experimental findings have been translated into early clinical trials beginning with a successful clinical report on three cases of patients with intermediate-to-high-grade liposarcoma in whom troglitazone administration induced histologic and biochemical differentiation in vivo as shown by extensive tumor-cell lipid accumulation and substantial NMR-detectable tumor triglyceride increases compared with pretreatment biopsies, accompanied by marked reduction in Ki-67 expression [244].