Immunohistochemical studies have reported extremely high FASN levels in many pre-neoplastic lesions and cancers including breast, colorectum, prostate, bladder, ovary, esophagus, stomach, lung, oral tongue, oral cavity, head and neck, thyroid, and endometrium, and also in mesothelioma, nephroblastoma, retinoblastoma, soft tissue sarcomas, melanoma, and hepatocellular carcinoma [291,292]. This evidence concerns the gene FASN and cancer.