In addition to their antiproliferative effects, experimental evidence indicates that cardiac glycosides are effective apoptotic inducers through an increase in Fas and Tumor necrosis factor receptor 1 (TNFR1) expression and by Apo2L/TNF-related apoptosis-inducing ligand (TRAIL) in non-small-cell lung cancer [59-61]. The gene discussed is TNFSF10; the disease is non-small cell lung carcinoma.