Farnesylated Ras proteins are associated with mitogenic signal transduction in response to growth factor stimulation [326], whereas Rho subfamily proteins such as Rho, Rac1, and Cdc42, regulate signal transduction from receptors in the membrane in a variety of cellular events related with cell morphology, cell adhesion, cell motility, cell growth, and cancer cell metastasis [327,328]. This evidence concerns the gene RHO and cancer.