Shivapurkar et al. described a combination of 4 loci, APC, CDKN2A/p16, HS3ST2 (3OST2), and RASSF1A that serve as a good panel for early detection of NSCLC in sputum, with an AUC of 0.8 [113]. This evidence concerns the gene CDKN2A and non-small cell lung carcinoma.