Using this approach, Shames et al. identified 132 tumor-specific methylation candidates, 45 of which were further investigated, revealing seven potential lung cancer markers (ALDH1A3, BNC1, CCNA1, CTSZ, LOX, MSX1 and NRCAM) three of which showed frequent tumor-specific hypermethylation compared to non-tumors [124]. This evidence concerns the gene MSX1 and neoplasm.